I agree.
To me though the spread or whatever you want to call it can be unstoppable and can work anywhere if you have the right QB to run it. I just think you have to hit it just right though, and turning over players every 3-4 years and you can be screwed real quick.
I think the problem you run into in the SEC is that defenses are so stout and have fresh legs rotating all the time that it is harder to be successful long term with the offense. The spread getting stopped one time and having a shitacular defense can cause a loss.
As to paragraph one...It can work anywhere, if you have talent that can compete with your competition. The second part of that thought, though, every offense has to deal with turnover. The key is coaching it, evolving it, and tweaking to fit variations is talent sets. Sumlin, for instance, doesn't really look to be a QB run type team, but he's letting Johnny Football do his thing, within the context of the overall philosophy. Not trying to fit a square peg in a round hole if you will.
Agree with paragraph 2. I'll even add, that you can have a just a moderately off day on offense, and have a shittastic D cost you a game.